| Regulating Pair |
| Introduced Variation |
Overexpression of KRAS |
Protein Info
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| Induced Change |
Pyrrole-2-carboxylic acid concentration: decrease (FC = 0.56) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of pyrrole-2-carboxylic acid concentration after KRAS overexpression through LC-MS based metabolomics. |
| Disease Status |
Lung cancer |
ICD-11: 2C25 |
| Organ/Tissue/Cell Line |
NCI-H1299 cells (Human non-small lung cancer cells) |
Lung |
| Subcellular Location |
Membrane (Cell membrane); Cytoplasm (Cytoplasmic side; Cytosol) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of KRAS leads to the decrease of pyrrole-2-carboxylic acid levels compared with control group in NCI-H1299 cells. |
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| References |
| 1 |
Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells. Oncotarget. 2014 Jul 15;5(13):4722-31.
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