| Regulating Pair |
| Introduced Variation |
Knockout of Taldo1 |
Protein Info
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| Induced Change |
Guanine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of guanine concentration after Taldo1 knockout through HPLC/MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
NIH-3T3 cells (Mouse embryonic fibroblasts) |
Embryo |
| Subcellular Location |
Cytoplasm |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Taldo1 leads to the increase of guanine levels compared with control group in NIH-3T3 cells. |
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| References |
| 1 |
Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network. Sci Rep. 2016 Oct 5;6:34648.
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