| Regulating Pair |
| Introduced Variation |
Knockout (CRISPR/Cas9 sgRNA) of Pdxk |
Protein Info
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| Induced Change |
Spermidine concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of spermidine concentration after Pdxk knockout through MSMS spectra based metabolomics. |
| Disease Status |
Acute myeloid leukaemia |
ICD-11: 2A60 |
| Organ/Tissue/Cell Line |
Nras (G12D)/MLL-AF9 leukemia cells |
Bone narrow |
| Subcellular Location |
Cytoplasm (Cytosol) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Pdxk leads to the decrease of spermidine levels compared with control group in Nras/MLL-AF9 leukemia cells. |
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| References |
| 1 |
Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell. 2020 Jan 13;37(1):71-84.e7.
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