| Regulating Pair |
| Introduced Variation |
Overexperisson of SLC7A5 |
Protein Info
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| Induced Change |
Valine concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-valine concentration after SLC7A5 and SLC7A8 co-overexperisson through 3H-labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Oocytes |
Ovarian |
| Subcellular Location |
Membrane (Cell membrane; Apical cell membrane); Lysosome (Lysosome membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that co-overexperisson of SLC7A5 and SLC7A8 leads to the decrease of valine levels compared with control group in oocytes. |
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| References |
| 1 |
Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem. 1999 Jul 9;274(28):19738-44.
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