| Regulating Pair |
| Introduced Variation |
Knockout of BLVRB |
Protein Info
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| Induced Change |
Malic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of malic acid concentration after BLVRB knockout through LC/MS/MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
PSCs cells (Pluripotent stem cells) |
Proximal tubular |
| Subcellular Location |
Cytoplasm |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockout of BLVRB leads to the decrease of malic acid levels compared with control group in PSCs cells. |
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| References |
| 1 |
Heme degradation enzyme biliverdin IX reductase is required for stem cell glutamine metabolism. Biochem J. 2018 Mar 29;475(6):1211-1223.
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