| Regulating Pair |
| Introduced Variation |
Knockout of Cth |
Protein Info
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| Induced Change |
UDP-N-acetylglucosamine concentration: increase (FC = 2.17) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of uridine diphosphate-N-acetylglucosamine concentration after Cth knockout through LC/MS/MS (using negative ion model) based metabolomics. |
| Disease Status |
Organic acid disorderss |
ICD-11: 5C50 |
| Organ/Tissue/Cell Line |
Red blood cells |
Blood |
| Subcellular Location |
Cytoplasm |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Cth leads to the increase of UDP-N-acetylglucosamine levels compared with control group in red blood cells. |
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| References |
| 1 |
Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes. Oxid Med Cell Longev. 2021 Feb 13;2021:8877691.
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