| Regulating Pair |
| Introduced Variation |
Knockout of FLNB |
Protein Info
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| Induced Change |
Argininosuccinic acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of argininosuccinic acid concentration after FLNB knockout through CE-TOFMS (Capillary electrophoresis time-of-flight mass spectrometry) based metabolomics. |
| Disease Status |
hydronephrosis |
ICD-11: GB56 |
| Organ/Tissue/Cell Line |
Renal tubular epithelial cells |
Kidney |
| Subcellular Location |
Cytoplasm (Cell cortex; Cytoskeleton; Stress fiber; Myofibril; Sarcomere; Z line) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockout of FLNB leads to the increase of argininosuccinic acid levels compared with control group in renal tubular epithelial cells. |
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| References |
| 1 |
A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia. Cell Rep. 2013 May 30;3(5):1440-8.
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