Details of Experiment

Regulating Pair
       Introduced Variation Knockout of ATP13A2 Protein Info
       Induced Change Putrescine concentration: decrease Metabo Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair [1]
       Method Quantifying the change of putrescine concentration after ATP13A2 knockout through kit detection.
       Disease Status Brain cancer ICD-11: 2A00
       Organ/Tissue/Cell Line SH-SY5Y cells(Human neuroblastoma cells) Brain neuroblastoma
metastatic site of bone marrow
       Subcellular Location Lysosome (Lysosome membrane); Endosome (Late endosome membrane; Multivesicular body membrane); Cytoplasm (Cytoplasmic vesicle; Autophagosome membrane)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that knockout of ATP13A2 leads to the decrease of putrescine levels compared with control group in SH-SY5Y cells.
References
1 ATP13A2 deficiency disrupts lysosomal polyamine export. Nature. 2020 Feb;578(7795):419-424.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.