| Regulating Pair |
| Introduced Variation |
Knockout of PHGDH |
Protein Info
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| Induced Change |
Phosphoserine concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of phosphoserine concentration after PHGDH knockout through LCMS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
SK-Me128 cells (Human melanoma cells) |
Skin |
| Subcellular Location |
Cytoplasm (Cytosol; Extracellular exosome) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockout of PHGDH leads to the decrease of phosphoserine levels compared with control group in SK-Me128 cells. |
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| References |
| 1 |
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011 Jul 31;43(9):869-74.
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