| Regulating Pair |
| Introduced Variation |
Recombinant protein addition of TGFB1 |
Protein Info
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| Induced Change |
Lactic acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 2-hydroxypropanoic acid concentration after TGFB1 recombinant protein addition through kit detection. |
| Disease Status |
Brain cancer |
ICD-11: 2A00 |
| Organ/Tissue/Cell Line |
T98G cells (Human glioblastoma cells) |
Brain |
| Subcellular Location |
Secreted (extracellular space; Extracellular matrix) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that recombinant protein addition of TGFB1 leads to the increase of lactic acid levels compared with control group in T98G cells. |
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| References |
| 1 |
TGF-1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells. FEBS J. 2017 Oct;284(20):3437-3454.
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