| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of CS |
Protein Info
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| Induced Change |
Orotic acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of orotic acid concentration after CS knockdown through GCMS based metabolomics. |
| Disease Status |
Lung cancer |
ICD-11: 2C25 |
| Organ/Tissue/Cell Line |
U2OS cells (Human osteosarcoma cells) |
Human Osteosarcoma |
| Subcellular Location |
Mitochondrion (Mitochondrion matrix) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of CS leads to the increase of orotic acid levels compared with control group in U2OS cells. |
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| References |
| 1 |
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 2015 Nov 19;527(7578):379-383.
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