| Regulating Pair |
| Introduced Variation |
Mutation (R132H) of IDH1 |
Protein Info
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| Induced Change |
Oxoglutaric acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of oxoglutaric acid concentration after IDH1 mutant through kit detection. |
| Disease Status |
Brain cancer |
ICD-11: 2A00 |
| Organ/Tissue/Cell Line |
U87MG cells (Human glioblastoma cells) |
Brain |
| Subcellular Location |
Cytoplasm (Cytosol); Peroxisome |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that R132H mutation of IDH1 leads to the decrease of oxoglutaric acid levels compared with control group in U87MG cells. |
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| References |
| 1 |
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009 Apr 10;324(5924):261-5.
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