| Regulating Pair |
| Introduced Variation |
Overexpression of SLC36A1 |
Protein Info
|
| Induced Change |
Proline concentration: increase (FC = 4.80) |
Metabo Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-proline concentration after SLC36A1 overexpression through Both flux studies using radiolabeled amino acids and the two-electrode voltage-clamp technique allowed electrogenic H+/amino acid symport to be demonstrated. based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Xenopus laevis oocytes |
N.A. |
| Subcellular Location |
Membrane (Cell membrane); Lysosome (Lysosome membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Details |
It is reported that overexpression of SLC36A1 leads to the increase of proline levels compared with control group in xenopus laevis oocytes. |
|
|
|
|
|
|
|
| References |
| 1 |
A cluster of proton/amino acid transporter genes in the human and mouse genomes. Genomics. 2003 Jul;82(1):47-56.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
