Details of Experiment

Regulating Pair
Introduced Variation	Glutamine absence (16 hours)	Metabo Info
Induced Change	cDNA FLJ33079 fis, clone TRACH2000306, highly similar to Dimethylglycine dehydrogenase, mitochondrial protein abundance levels: increase (FC = 5.21)	Protein Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the variation of cDNA FLJ33079 fis, clone TRACH2000306, highly similar to Dimethylglycine dehydrogenase, mitochondrial protein abundances after glutamine absence through quantitative LC-MS/MS analysis.
Disease Status	Hepatocellular carcinoma	ICD-11: 2C12
Organ/Tissue/Cell Line	HepG2 cells (Human hepatocellular carcinoma cells)	Liver
Tested Species	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Details	It is reported that glutamine absence causes the increase of cDNA FLJ33079 fis, clone TRACH2000306, highly similar to Dimethylglycine dehydrogenase, mitochondrial protein abundance compared with control group.

References
1	Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid -oxidation pathway in HepG2 cells. Amino Acids. 2016 May;48(5):1297-307.

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