| Regulating Pair |
| Introduced Variation |
Glutamine absence (2 hours) |
Metabo Info
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| Induced Change |
PDPK1 protein expression levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of PDPK1 protein abundances after glutamine absence through western blot analysis. |
| Disease Status |
Hepatocellular carcinoma |
ICD-11: 2C12 |
| Organ/Tissue/Cell Line |
HepG2 cells (Human hepatocellular carcinoma cells) |
Liver |
| Subcellular Location |
Cytoplasm; Nucleus; Membrane (Cell membrane); Cell junction (Focal adhesion) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that glutamine absence causes the increase of PDPK1 protein expression compared with control group in the HepG2 cells. |
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| References |
| 1 |
Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid -oxidation pathway in HepG2 cells. Amino Acids. 2016 May;48(5):1297-307.
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