| Regulating Pair |
| Introduced Variation |
Glutamine addition (1 hours) |
Metabo Info
|
| Induced Change |
MTOR protein activity levels: increase |
Protein Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of MTOR protein activity abundances after L-glutamine addition through In-cell western assay analysis. |
| Disease Status |
Ovarian cancer |
ICD-11: 2C73 |
| Organ/Tissue/Cell Line |
Hela cells (Human cervix carcinoma cells) |
Cervix uteri |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum membrane); Cytoplasm (Cytoplasmic side); Golgi apparatus (Golgi apparatus membrane); Mitochondrion (Mitochondrion outer membrane); Nucleus (PML body); Lysosome (Lysosome membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Details |
It is reported that glutamine addition causes the increase of MTOR protein activity compared with control group in the Hela cells. |
|
|
|
|
|
|
|
| References |
| 1 |
Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
