| Regulating Pair |
| Introduced Variation |
Leucine decrease (24 hours) |
Metabo Info
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| Induced Change |
MTOR protein phosphorylation levels: decrease |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of MTOR protein phosphorylation abundances after leucine decrease through western blot analysis. |
| Disease Status |
Hepatocellular carcinoma |
ICD-11: 2C12 |
| Organ/Tissue/Cell Line |
HepG2 cells (Human hepatocellular carcinoma cells) |
Liver |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum membrane); Cytoplasm (Cytoplasmic side); Golgi apparatus (Golgi apparatus membrane); Mitochondrion (Mitochondrion outer membrane); Nucleus (PML body); Lysosome (Lysosome membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that leucine decrease causes the decrease of MTOR protein phosphorylation compared with control group in the HepG2 cells. |
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| References |
| 1 |
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes. 2011 Mar;60(3):746-56.
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