| Regulating Pair |
| Introduced Variation |
Glucose decrease (24 hours) |
Metabo Info
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| Induced Change |
OGT protein phosphorylation levels: increase (FC = 5) |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of OGT protein phosphorylation abundances after glucose decrease through western blot analysis. |
| Disease Status |
Bladder Cancer |
ICD-11: 2C94 |
| Organ/Tissue/Cell Line |
Human bladder cancer cells |
Bladder |
| Subcellular Location |
Nucleus; Cytoplasm; Mitochondrion; Membrane; Cytoplasm; Nucleus; Membrane (Cell membrane); Mitochondrion ( Mitochondrion membrane); Cell projection |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that glucose decrease causes the increase of OGT protein phosphorylation compared with control group in the T24 human Bladder Cancer cells. |
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| References |
| 1 |
O-GlcNAc-specific antibody CTD110.6 cross-reacts with N-GlcNAc2-modified proteins induced under glucose deprivation. PLoS One. 2011 Apr 19;6(4):e18959.
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