| Regulating Pair |
| Introduced Variation |
Glutamine decrease (0.5 hours) |
Metabo Info
|
| Induced Change |
TJP1 protein expression levels: decrease |
Protein Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of TJP1 protein abundances after glutamine decrease through immunoblotting analysis. |
| Disease Status |
Colon cancer |
ICD-11: 2B90 |
| Organ/Tissue/Cell Line |
Caco-2 cells (Human colon cancer cells) |
Colon |
| Subcellular Location |
Membrane (Cell membrane); Cytoplasm (Cytoplasmic side); Cell junction (Tight junction; Gap junction); Cell projection (Podosome) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Details |
It is reported that glutamine decrease causes the decrease of TJP1 protein expression compared with control group in the Caco-2 cells. |
|
|
|
|
|
|
|
| References |
| 1 |
Glutamine regulates Caco-2 cell tight junction proteins. Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G726-33.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
