| Regulating Pair |
| Introduced Variation |
Phenylalanine addition (0.08 hours) |
Metabo Info
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| Induced Change |
MAPK1 protein phosphorylation levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of MAPK1 protein phosphorylation abundances after L-phenyLalanine addition through western blot analysis. |
| Disease Status |
Diabetes mellitus |
ICD-11: 5A14 |
| Organ/Tissue/Cell Line |
SK-N-MC cells (Human neuroepithelioma adherent cells) |
Brain |
| Subcellular Location |
Cytoplasm (Cytoskeleton; Spindle); Nucleus; Centrosome; Cytoplasm; Membrane (caveola) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that phenylalanine addition causes the increase of MAPK1 protein phosphorylation compared with control group in the SK-N-MC cells. |
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| References |
| 1 |
Computer-aided discovery of aromatic l--amino acids as agonists of the orphan G protein-coupled receptor GPR139. J Chem Inf Model. 2014 Jun 23;54(6):1553-7.
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