| Regulating Pair |
| Introduced Variation |
Leucine addition (72 hours) |
Metabo Info
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| Induced Change |
PPP1CA protein expression levels: decrease |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of PPP1CA protein abundances after leucine addition through 2-DGE analysis. |
| Disease Status |
Type 2 diabetes mellitus |
ICD-11: 5A11 |
| Organ/Tissue/Cell Line |
INS-1E cells (Insulin immunoreactive cells) |
Pancreas islet |
| Subcellular Location |
Cytoplasm; Nucleus (Nucleoplasm; Nucleolus) |
| Tested Species |
Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
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| Details |
It is reported that leucine addition causes the decrease of PPP1CA protein expression compared with control group in the INS-1E cells. |
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| References |
| 1 |
Chronic exposure to leucine in vitro induces -cell dysfunction in INS-1E cells and mouse islets. J Endocrinol. 2012 Oct;215(1):79-88.
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