| Regulating Pair |
| Introduced Variation |
Calcium addition (0.08 hours) |
Metabo Info
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| Induced Change |
TRPM4 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1], [2] |
| Method |
Quantifying the variation of TRPM4 protein activity abundances after Ca2+ addition through whole-cell currents analysis. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
HEK 293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane); Endoplasmic reticulum; Golgi apparatus; Membrane (Cell membrane); Endoplasmic reticulum |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that calcium addition causes the increase of TRPM4 protein activity compared with control group in the HEK293 cells. |
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| References |
| 1 |
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem. 2005 Feb 25;280(8):6423-33.
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| 2 |
A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity. Mol Pharmacol. 2006 Apr;69(4):1413-20.
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