| Regulating Pair |
| Introduced Variation |
Lactic acid addition (6 hours) |
Metabo Info
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| Induced Change |
HIF1A protein expression levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of HIF1A protein abundances after lactate addition through western blot analysis. |
| Disease Status |
Cervical Cancer |
ICD-11: 2C77 |
| Organ/Tissue/Cell Line |
Hela cells (Human cervix carcinoma cells) |
Cervix uteri |
| Subcellular Location |
Cytoplasm; Nucleus (Nucleus speckle) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that lactic acid addition causes the increase of HIF1A protein expression compared with control group in the Hela cells. |
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| References |
| 1 |
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells. Cell Cycle. 2016;15(1):72-83.
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