| Regulating Pair |
| Introduced Variation |
Bile acid addition (36 hours) |
Metabo Info
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| Induced Change |
NR1H4 protein abundance levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of NR1H4 protein activity abundances after bile acid addition through immunoblot analysis. |
| Disease Status |
Hepatocellular carcinoma |
ICD-11: 2C12 |
| Organ/Tissue/Cell Line |
HepG2 cells (Human hepatocellular carcinoma cells) |
Liver |
| Subcellular Location |
Nucleus |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that bile acid addition causes the increase of NR1H4 protein abundance compared with control group in the HepG2 cells. |
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| References |
| 1 |
Identification of a nuclear receptor for bile acids. Science. 1999 May 21;284(5418):1362-5.
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