| Regulating Pair |
| Introduced Variation |
Arginine decrease (48 hours) |
Metabo Info
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| Induced Change |
HSPA5 protein abundance levels: decrease (FC = 3.0) |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of HSPA5 protein abundances after arginine decrease through quantitative LC-MS/MS analysis or 2-DE analysis. |
| Disease Status |
Colon cancer |
ICD-11: 2B90 |
| Organ/Tissue/Cell Line |
Caco-2 cells (Human colon cancer cells) |
Colon |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum lumen); Melanosome; Cytoplasm |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that arginine decrease causes the decrease of HSPA5 protein abundance compared with control group in the Caco-2 cells. |
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| References |
| 1 |
Arginine deficiency in preconfluent intestinal Caco-2 cells modulates expression of proteins involved in proliferation, apoptosis, and heat shock response. Proteomics. 2007 Feb;7(4):565-577.
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