| Regulating Pair |
| Introduced Variation |
Dehydroepiandrosterone sulfate addition (1h) |
Metabo Info
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| Induced Change |
TRPM3 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of TRPM3 protein activity abundances after DHEA sulphate addition through whole-cell patch-clamp or Fura-2 analysis. |
| Disease Status |
Diabetes mellitus |
ICD-11: 5A14 |
| Organ/Tissue/Cell Line |
Trpm3-transfected HEK293 cells (Human embryonic kidney cells transfected with Trpm3) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that dehydroepiandrosterone sulfate addition causes the increase of TRPM3 protein activity compared with control group in the Trpm3-transfected HEK293 cells. |
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| References |
| 1 |
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol. 2008 Dec;10(12):1421-30.
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