| Regulating Pair |
| Introduced Variation |
4-Hydroxynonenal addition (0.5 hour) |
Metabo Info
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| Induced Change |
TRPA1 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of TRPA1 protein activity abundances after 4-hydroxynonenal addition through live-cell calcium imaging analysis. |
| Disease Status |
Neuropathic pain |
ICD-11: 8E43 |
| Organ/Tissue/Cell Line |
HEK 293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
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| Details |
It is reported that 4-hydroxynonenal addition causes the increase of TRPA1 protein activity compared with control group in the HEK293 cells. |
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| References |
| 1 |
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24.
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