| Regulating Pair |
| Introduced Variation |
Nicotinic acid addition (2 hours) |
Metabo Info
|
| Induced Change |
HCAR2 protein activity levels: increase |
Protein Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of HCAR2 protein activity abundances after nicotinic acid addition through GTPS binding assay analysis. |
| Disease Status |
Diabetic acidosis |
ICD-11: 5A22 |
| Organ/Tissue/Cell Line |
HEK 293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Details |
It is reported that nicotinic acid addition causes the increase of HCAR2 protein activity compared with control group in the HEK293 cells. |
|
|
|
|
|
|
|
| References |
| 1 |
Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J Biol Chem. 2009 Aug 14;284(33):21928-21933.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
