| Regulating Pair |
| Introduced Variation |
Phenylalanine addition (48 hours) |
Metabo Info
|
| Induced Change |
GPR139 protein activity levels: increase |
Protein Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of GPR139 protein activity abundances after L-phenyLalanine addition through GTPS binding assay analysis or calcium mobilization assay analysis. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
COS-7 cells (African green monkey Renal fibroblasts) |
Kidney |
| HEK 293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Details |
It is reported that phenylalanine addition causes the increase of GPR139 protein activity compared with control group in the COS-7 cells and HEK 293 cells. |
|
|
|
|
|
|
|
| References |
| 1 |
GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine. Mol Pharmacol. 2015 Nov;88(5):911-25.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
