| Regulating Pair |
| Introduced Variation |
AICAR addition (24 hours) |
Metabo Info
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| Induced Change |
PCK1 mRNA levels: decrease (FC = 0.19) |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of PCK1 mRNA levels abundances after AICAR addition through quantitative real-time RT-PCR analysis. |
| Disease Status |
Obesity |
ICD-11: 5B81 |
| Organ/Tissue/Cell Line |
N.A. |
Liver |
| Subcellular Location |
Cytoplasm (Cytosol); Endoplasmic reticulum |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that AICAR addition causes the decrease of PCK1 mRNA levels compared with control group in the mouse liver. |
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| References |
| 1 |
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 2006 Jun;3(6):403-16.
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