| Regulating Pair |
| Introduced Variation |
Leucine decrease (2 hours) |
Metabo Info
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| Induced Change |
HSPA5 protein phosphorylation levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of HSPA5 protein phosphorylation abundances after leucine decrease through 2DPAGE analysis. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
C2C12 cells (Mouse myoblasts) |
Muscle |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum lumen); Cytoplasm |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that leucine decrease causes the increase of HSPA5 protein phosphorylation compared with control group in the C2C12 myoblasts. |
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| References |
| 1 |
Phospho-proteomic approach to identify new targets of leucine deprivation in muscle cells. Anal Biochem. 2008 Oct 1;381(1):148-50.
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