Details of Experiment

Regulating Pair
       Introduced Variation Tryptophan decrease (12 hours) Metabo Info
       Induced Change EIF2S1 protein phosphorylation levels: increase Protein Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair [1]
       Method Quantifying the variation of EIF2S1 protein phosphorylation abundances after tryptophan decrease through western blot analysis.
       Disease Status Cervical Cancer ICD-11: 2C77
       Organ/Tissue/Cell Line Hela cells (Human cervix carcinoma cells) Cervix uteri
C33A cells (human cervical cancer cells) Cervix uteri
       Subcellular Location Cytoplasm (Stress granule)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that tryptophan decrease causes the increase of EIF2S1 protein phosphorylation compared with control group in the Hela cells and C33A cells.
References
1 The High-Risk Human Papillomavirus E6 Oncogene Exacerbates the Negative Effect of Tryptophan Starvation on the Development of Chlamydia trachomatis. PLoS One. 2016 Sep 22;11(9):e0163174.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.