| Regulating Pair |
| Introduced Variation |
AICAR addition (1 hours) |
Metabo Info
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| Induced Change |
ACACA protein phosphorylation levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of ACACA protein phosphorylation abundances after AICAR addition through western blot analysis. |
| Disease Status |
Insulin-resistance syndromes |
ICD-11: 5A44 |
| Organ/Tissue/Cell Line |
Primary Murine Myocardiocytes |
Liver |
| Subcellular Location |
Cytoplasm (Cytosol) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that AICAR addition causes the increase of ACACA protein phosphorylation compared with control group in the primary rat hepatocytes. |
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| References |
| 1 |
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 2006 Jun;3(6):403-16.
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