Regulating Pair
       Introduced Variation Glucose decrease (4 hours) Metabo Info
       Induced Change IFNB1 mRNA levels: increase (FC = 2) Protein Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair [1]
       Method Quantifying the variation of IFNB1 mRNA levels abundances after glucose decrease through quantitative real-time RT-PCR analysis.
       Disease Status Acute lymphoblastic leukemia ICD-11: 2B33
       Organ/Tissue/Cell Line HEK 293 cells (Human embryonic kidney cells) Kidney
RAW 264.7 cells (Mouse mononuclear macrophage leukemic cells) Peripheral blood
THP-1 cells (Human monocytic leukemia cells) Peripheral blood
       Subcellular Location Secreted
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that glucose decrease causes the increase of IFNB1 mRNA levels compared with control group in the HEK 293 cells, RAW 264.7 cells and THP-1 cells.
References
1 Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. 2019 Jun 27;178(1):176-189.e15.

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