| Regulating Pair |
| Introduced Variation |
Cholesterol addition (24h) |
Metabo Info
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| Induced Change |
RORC protein binding activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of RORC protein binding activity abundances after cholesterol addition through alphascreen assay analysis. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
COS-7 cells (African green monkey Renal fibroblasts) |
Kidney |
| Subcellular Location |
Nucleus |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that cholesterol addition causes the increase of RORC protein binding activity compared with control group in the COS-7 cells. |
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| References |
| 1 |
Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol Endocrinol. 2010 May;24(5):923-9.
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