Details of Metabolite

General Information of MET (ID: META01446)
Name 2,4-Dihydroxyglutarate
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
Structure
2D MOL
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Lyases (EC 4)
            Dihydrodipicolinate synthase-like (DHDPSL) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (patients: bi-allelic mutations) of HOGA1
                      Induced Change 2,4-Dihydroxyglutarate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Carbohydrate metabolism disorders [ICD-11: 5C51]
                      Details It is reported that mutation (patients with bi-allelic mutations) of HOGA1 leads to the increase of 2,4-dihydroxyglutarate levels compared with control group.
References
1 Primary hyperoxaluria type III--a model for studying perturbations in glyoxylate metabolism. J Mol Med (Berl). 2012 Dec;90(12):1497-504.

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