General Information of MET (ID: META01425)
Name	LDL cholesterol
Structure Type	Lipid-related molecules
Structure
	2D MOL
Regulatory Network

Full List of Protein(s) Regulating This Metabolite
Transferases (EC 2)
Squalene synthase (FDFT1)		Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
Detailed Information	Protein   Info click to show the details of this protein
Regulating Pair	Experim Info click to show the details of experiment for validating this pair					[1]
Introduced Variation	Mutation of FDFT1
Induced Change	LDL cholesterol concentration: decrease
Summary	Introduced Variation         Induced Change
Disease Status	Lipid metabolism disorders [ICD-11: 5C52]
Details	It is reported that mutation (patients with variants in FDFT1) of FDFT1 leads to the decrease of LDL cholesterol levels compared with control group.

References
1	Squalene Synthase Deficiency: Clinical, Biochemical, and Molecular Characterization of a Defect in Cholesterol Biosynthesis. Am J Hum Genet. 2018 Jul 5;103(1):125-130.

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