Details of Metabolite

General Information of MET (ID: META01273)
Name Glycylsarcosine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Glycylsarcosine; 29816-01-1; Glycyl-sarcosine; Gly-Sar; H-Gly-Sar-OH; 2-(2-amino-N-methylacetamido)acetic acid; N-Glycylsarcosine; Gly-Sarcosin; 2-[(2-aminoacetyl)-methylamino]acetic acid; UNII-2JE8SG6VDT; 2JE8SG6VDT; CHEMBL175737; MFCD00038193; N-glycyl-Sar-OH; EINECS 249-875-2; Gly-Sar-OH; [3H]GlySar; NSC 206288; glycyl-N-methylglycine; [3H]-GlySar; tritiated glycylsarcosine; N-glycyl-N-methylglycine; ACMC-209hb7; Glycine, N-glycyl-N-methyl-; SCHEMBL510835; GTPL4659; GTPL9505
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
93131
Formula
C5H10N2O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 146.14 Topological Polar Surface Area 83.6
XlogP -3.9 Complexity 146
Heavy Atom Count 10 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Proton-dependent oligopeptide transporter (POT/PTR)
            Solute carrier family 15 member 4 (SLC15A4) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (L14A, L15A, L318A, V319A) of SLC15A4
                      Induced Change Glycylsarcosine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that mutation (L14A and L15A or L318A and V319A) of SLC15A4 leads to the increase of glycylsarcosine levels compared with control group.
References
1 Functional Characterization of Human Peptide/Histidine Transporter 1 in Stably Transfected MDCK Cells. Mol Pharm. 2018 Feb 5;15(2):385-393.

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