Details of Metabolite

General Information of MET (ID: META01262)
Name Fluorodeoxyglucose F18
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Fluorodeoxyglucose F18; UNII-0Z5B2CJX4D; 2-Deoxy-2(F-18)fluoro-2-D-glucose; 0Z5B2CJX4D; CHEBI:49136; 63503-12-8; 18F-Flurodeoxyglucose; 18F Fluorodeoxyglucose; Fluorine-18 Fluorodeoxyglucose; 2-Deoxy-2-(18F)fluoroglucose; 2-Deoxy-2-fluoro-18F-D-glucose; (18F)-2-Fluoro-2-deoxy-D-glucose; 2-Deoxy-2-(fluoro-18F)-D-glucose; Fludeoxyglucose, F-18; 18-F FDG; Fludeoxyglucose F 18 [USAN]; CHEMBL1808698; (18F)-FDG; DTXSID40212908; DB09502; D-Glucose, 2-deoxy-2-(fluoro-18F)-; 2-deoxy-2-((18)F)fluoro-aldehydo-D-glucose; (2R,3S,4R,5R)-2-(18F)fluoranyl-3,4,5,6-tetrahydroxyhexanal
Structure Type   Fatty alcohols  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty alcohols
PubChem CID
68374
Formula
C6H11FO5
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=68374"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 181.15 Topological Polar Surface Area 98
XlogP -2.4 Complexity 142
Heavy Atom Count 12 Rotatable Bond Count 5
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Sugar transporter (ST)
            Facilitated glucose transporter 1 (SLC2A1A) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Downregulation of slc2a1a caused by Yap loss-of-function mutation
                      Induced Change Fluorodeoxyglucose F18 concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that downregulation of slc2a1a caused by Yap loss-of-function mutation leads to the increase of fluorodeoxyglucose f18 levels compared with control group.
      Transcriptional coactivator (TC)
            Transcriptional coactivator YAP1 (yap1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Decrease of Yap mRNA caused by Yap loss-of-function mutation
                      Induced Change Fluorodeoxyglucose F18 concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that decrease of Yap mRNA caused by Yap loss-of-function mutation leads to the increase of fluorodeoxyglucose f18 levels compared with control group.
References
1 Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. EMBO J. 2018 Nov 15;37(22):e100294.

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