Details of Metabolite

General Information of MET (ID: META01255)
Name 3-Hydrazono-1-methyl-1,3-dihydro-indol-2-one
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3265-23-4; 3-Hydrazono-1-methyl-1,3-dihydro-indol-2-one; 3-hydrazinylidene-1-methyl-2,3-dihydro-1H-indol-2-one; SCHEMBL7100709; 3-diazenyl-1-methylindol-2-ol; SCHEMBL21999876; HMS1782P07; 3-Hydrazono-1-methylindolin-2-one; 1-Methyl-3-hydrazonoindoline-2-one; AKOS034461887; ZINC100260132; MCULE-5358619725; NE25652; EN300-04229; 1H-Indole-2,3-dione, 1-methyl-, 3-hydrazone; J-512608; (3Z)-1-Methyl-1H-indole-2,3-dione 3-hydrazone #; Z56860354; 1-HEXADECANOYL-2-[CIS-9-OCTADECENOYL]-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
Structure Type   Indoles  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Indoles and derivatives
Indoles
PubChem CID
600234
Formula
C9H9N3O
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=600234"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 175.19 Topological Polar Surface Area 61.4
XlogP 2.6 Complexity 209
Heavy Atom Count 13 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change 3-Hydrazono-1-methyl-1,3-dihydro-indol-2-one concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of 3-hydrazono-1-methyl-1,3-dihydro-indol-2-one levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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