Details of Metabolite

General Information of MET (ID: META01244)
Name Lumichrome
Synonyms   Click to Show/Hide Synonyms of This Metabolite
lumichrome; 7,8-Dimethylalloxazine; 1086-80-2; 7,8-dimethylbenzo[g]pteridine-2,4(1H,3H)-dione; Riboflavin lumichrome; UNII-99U1UDJ2HM; Benzo[g]pteridine-2,4(1H,3H)-dione, 7,8-dimethyl-; 99U1UDJ2HM; Benzo(g)pteridine-2,4(1H,3H)-dione, 7,8-dimethyl-; 7,8-dimethylisoalloxazine; CHEBI:17781; MFCD00005021; 7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione; LUM; 7,8-Dimethylbenzo(g)pteridine-2,4(1H,3H)-dione; 7,8-dimethyl-3,10-dihydrobenzo[g]pteridine-2,4-dione
Source Drug;Toxins/Pollutant
Structure Type Benzenoids
PubChem CID
5326566
Formula
C12H10N4O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 242.23 Topological Polar Surface Area 84
XlogP 1.1 Complexity 386
Heavy Atom Count 18 Rotatable Bond Count N.A.
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Lumichrome concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of lumichrome levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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