Details of Metabolite

General Information of MET (ID: META01225)
Name Proglumide
Synonyms   Click to Show/Hide Synonyms of This Metabolite
6620-60-6; 4-benzamido-5-(dipropylamino)-5-oxopentanoic acid; Proglumidum; Proglumida; Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-; W-5219; (+-)-4-Benzamido-N,N-dipropylglutaramic acid; Binoside; Xylamide; Nulsa; Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (+-)-; CHEMBL316561; CHEBI:32058; dl-proglumide; Milid; 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid; Gastrotopic; Midelid; Ulcutin; Milide; Xyde; DSSTox_CID_3516; DSSTox_RID_77060
Source Drug;Toxins/Pollutant
Structure Type Benzenoids
PubChem CID
4788
Formula
C16H22O10
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 374.34 Topological Polar Surface Area 155
XlogP -2 Complexity 592
Heavy Atom Count 26 Rotatable Bond Count 4
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 10
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Proglumide concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of proglumide levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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