Details of Metabolite

General Information of MET (ID: META01216)
Name PE(P-19:1(12Z)/0:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
PE(P-19:1/0:0); PE(P-19:1(12Z)/0:0); 1-(1Z,12Z-nonadecadienyl)-sn-glycero-3-phosphoethanolamine; LMGP02070003
Structure Type   Phosphate esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Organic phosphoric acids and derivatives
Phosphate esters
PubChem CID
42607471
Formula
C24H48NO6P
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=42607471"></iframe>
3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 477.6 Topological Polar Surface Area 111
XlogP 3.6 Complexity 501
Heavy Atom Count 32 Rotatable Bond Count 24
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            GTPase KRas (KRAS) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of KRAS
                      Induced Change PE(P-19:1(12Z)/0:0) concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lung cancer [ICD-11: 2C25]
                      Details It is reported that overexpression of KRAS leads to the decrease of PE(P-19:1(12Z)/0:0) levels compared with control group.
References
1 Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells. Oncotarget. 2014 Jul 15;5(13):4722-31.

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