Details of Metabolite

General Information of MET (ID: META01215)
Name 3-Hydroxybutyrate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-hydroxybutyrate; 3-hydroxybutanoate; beta-hydroxybutyrate; beta-hydroxybutanoate; 3-OH butyrate; 3-OH-butyrate; beta-hydroxy-n-butyrate; DL-3-Hydroxybutyrate; DTXSID9040976; CHEBI:37054; BDBM50270275; Q27117026
Structure Type   Beta hydroxy acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Hydroxy acids and derivatives
Beta hydroxy acids and derivatives
PubChem CID
3541112
Formula
C4H7O3-
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3541112"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 103.1 Topological Polar Surface Area 60.4
XlogP 0.1 Complexity 63.8
Heavy Atom Count 7 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Oxidoreductases (EC 1)
            Glyoxylate reductase/hydroxypyruvate reductase (GRHPR) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (patients: c.454dup (p.Thr152Asnfs*39)) of GRHPR
                      Induced Change 3-Hydroxybutyrate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Carbohydrate metabolism disorders [ICD-11: 5C51]
                      Details It is reported that mutation (patients with c.454dup (p.Thr152Asnfs*39)) of GRHPR leads to the increase of 3-hydroxybutyrate levels compared with control group.
References
1 Severe child form of primary hyperoxaluria type 2 - a case report revealing consequence of GRHPR deficiency on metabolism. BMC Med Genet. 2017 May 31;18(1):59.

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