Details of Metabolite

General Information of MET (ID: META01203)
Name L-Arabinono-1,4-lactone
Synonyms   Click to Show/Hide Synonyms of This Metabolite
L-Arabinono-1,4-lactone; L-Arabino-1,4-lactone; 51532-86-6; L-Arabonolactone; L-Arabonic acid-1,4-lactone; L-arabinonic acid gamma-lactone; L-Arabinonic acid, gamma-lactone; (3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-one; l-lyxonolactone; SCHEMBL918432; L-arabinonic acid-1,4-lactone; CHEBI:17100; ZINC1532709; AKOS006274109; L-Arabino-1,4-lactone, >=95.0% (GC); C01114; W-202940; Q27102209; (3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one
Structure Type   Gamma butyrolactones  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Lactones
Gamma butyrolactones
PubChem CID
191190
Formula
C5H8O5
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=191190"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 148.11 Topological Polar Surface Area 87
XlogP -1.4 Complexity 145
Heavy Atom Count 10 Rotatable Bond Count 1
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Lyases (EC 4)
            Cystathionine gamma-lyase (CTH) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Cth
                      Induced Change L-Arabinono-1,4-lactone concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Organic acid disorderss [ICD-11: 5C50]
                      Details It is reported that knockout of Cth leads to the decrease of L-Arabinono-1,4-lactone levels compared with control group.
References
1 Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes. Oxid Med Cell Longev. 2021 Feb 13;2021:8877691.

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