Details of Metabolite

General Information of MET (ID: META01195)
Name 2'-O-Methylcytidine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2'-O-Methylcytidine; 2140-72-9; Cytidine, 2'-O-methyl-; 2'-O-Methyl cytidine; O(2')-Methylcytidine; 4-amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one; UNII-5XD9IH2G27; 5XD9IH2G27; CHEBI:19228; MFCD00056067; O-2-Methylcytidine; 2''-O-Methylcytidine; PubChem11055; SCHEMBL64632; CHEMBL176605; DTXSID50943958; ZINC5998209; ANW-54599; ZB1481; AKOS015850975; AKOS015896935; 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one; AK-54700; DS-14587; AB0011995
Structure Type   Pyrimidine nucleosides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides/nucleotides
Pyrimidine nucleosides
PubChem CID
150971
Formula
C10H15N3O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 257.24 Topological Polar Surface Area 118
XlogP -1.6 Complexity 397
Heavy Atom Count 18 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Arylamine N-acetyltransferase 1 (NAT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of NAT1
                      Induced Change 2'-O-Methylcytidine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Breast cancer [ICD-11: 2C60]
                      Details It is reported that knockout of NAT1 leads to the decrease of 2'-o-Methylcytidine levels compared with control group.
References
1 CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. Sci Rep. 2020 Jun 17;10(1):9804.

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