Details of Metabolite

General Information of MET (ID: META01191)
Name 5,2'-O-Dimethyluridine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
5,2'-O-Dimethyluridine; 2'-O-Methyl-5- methyl uridine; 114952-97-5; 1-[4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione; Uridine,5-methyl-2-O-methyl- (9CI); ACMC-20mkxm; CHEBI:166841; VZ21913; AK163044; FT-0640311; A830668; 1-[4-hydroxy-5-(hydroxymethyl)-3-methoxy-2-oxolanyl]-5-methylpyrimidine-2,4-dione; 1-[5-(hydroxymethyl)-3-methoxy-4-oxidanyl-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
Structure Type   Pyrimidine nucleosides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Pyrimidine nucleosides
PubChem CID
14367009
Formula
C11H16N2O6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 272.25 Topological Polar Surface Area 108
XlogP -1.6 Complexity 423
Heavy Atom Count 19 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change 5,2'-O-Dimethyluridine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of 5,2'-o-dimethyluridine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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