Details of Metabolite

General Information of MET (ID: META01187)
Name 2'-O-Methylinosine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2'-O-methylinosine; 3881-21-8; 2'-O-Methyl-inosine; 2'-(o-Methyl)-inosine; MFCD01631008; 9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-ol; 2O-Methylinosine; SCHEMBL658713; 2'-O-METHYL-D-INOSINE; CHEBI:68467; DTXSID00435030; ZINC34149906; AKOS025402340; AC-8215; VZ21766; 881M218; J-700080; Q15632692; 9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one
Structure Type   Purine nucleosides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides/nucleotides
Purine nucleosides
PubChem CID
135412763
Formula
C11H14N4O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 282.25 Topological Polar Surface Area 118
XlogP -0.8 Complexity 420
Heavy Atom Count 20 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change 2'-O-Methylinosine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of 2'-o-Methylinosine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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