Details of Metabolite

General Information of MET (ID: META01184)
Name Glycerophosphorylethanolamine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1190-00-7; Glycerophosphorylethanolamine; 2-Aminoethyl (2,3-dihydroxypropyl) hydrogen phosphate; sn-Glycerol-3-phosphoethanolamine; 2-aminoethyl 2,3-dihydroxypropyl hydrogen phosphate; glycerophosphatidylethanolamine; glycerophosphoethanolamine; (+/-)-alpha-glycerophosphorylethanolamine; Phosphoric acid, mono(2-aminoethyl) mono(2,3-dihydroxypropyl) ester; glycerylphosphoethanolamine; SCHEMBL692470; CHEBI:52330; 3205AA; ANW-60230; FT-0688264; FT-0699527; 2-Aminoethyl (2,3-dihydroxypropyl)hydrogen phosphate; L-A-GLYCEROPHOSPHORYLETHANOLAMINE*FROM E COLI; Q27123382
Structure Type   Glycerophosphoethanolamines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerophospholipids
Glycerophosphoethanolamines
PubChem CID
5459861
HMDB ID
HMDB0059660
Formula
C5H14NO6P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
DrugBank ID
DB03484
ChEBI ID
16929
ChemSpider ID
4573608
Physicochemical Properties Molecular Weight 215.14 Topological Polar Surface Area 122
XlogP -5.5 Complexity 176
Heavy Atom Count 13 Rotatable Bond Count 7
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7
Function
sn-glycero-3-Phosphoethanolamine belongs to the class of organic compounds known as glycerophosphoethanolamines. These are glycerolipids characterized by an ethanolamine ester of glycerophosphoric acid. As is the case with diacylglycerols, glycerophosphoethanolamines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 atoms. sn-glycero-3-Phosphoethanolamine is a very strong basic compound (based on its pKa).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of TP53
                      Induced Change Glycerophosphorylethanolamine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of glycerophosphorylethanolamine levels compared with control group.
References
1 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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