Details of Metabolite

General Information of MET (ID: META01126)
Name RvD1-ME
Synonyms   Click to Show/Hide Synonyms of This Metabolite
RvD1-ME; RvD1-methyl ester; methyl (4Z,7S,8R,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoate; GTPL5555; ZINC207090842; Q27088649; (4Z,7S,8R,9E,11E,13Z,15E,17S,19Z)-7,8,17-Trihydroxy-4,9,11,13,15,19-docosahexaenoic acid methyl ester
Source Endogenous;Food
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
71519431
Formula
C23H34O5
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=71519431"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 390.5 Topological Polar Surface Area 87
XlogP 3.4 Complexity 570
Heavy Atom Count 28 Rotatable Bond Count 15
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      GPCR rhodopsin (GPCR-1)
            FMLP-related receptor I (FPR2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation RvD1-ME addition (1 hours)
                      Induced Change FPR2 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Peritonitis [ICD-11: DC50]
                      Details It is reported that RvD1-ME addition causes the increase of FPR2 protein activity compared with control group.
            G-protein coupled receptor 32 (GPR32) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation RvD1-ME addition (1 hours)
                      Induced Change GPR32 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Peritonitis [ICD-11: DC50]
                      Details It is reported that RvD1-ME addition causes the increase of GPR32 protein activity compared with control group.
References
1 Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May;180(5):2018-27.

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